Topical diphenyl diselenide mice research
WebFeb 1, 2003 · Administration of 200 μmol/kg diphenyl diselenide (i.p.) induced 100% seizures in mice and caused 50% death in 72 h. All mice died after doses higher than 350 μmol/kg of diphenyl diselenide. At lower doses (25–150 μmol/kg), no seizures were observed. The LD 50 calculated and the 95% confident interval was 210 μmol/kg … WebThe aim of this study was to verify the effect of diphenyl diselenide (PhSe) 2 on hepatic nucleotidases and on the concentration of purines in mice infected by Toxoplasma gondii. …
Topical diphenyl diselenide mice research
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WebOct 28, 2010 · Since the successful use of the organoselenium drug ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there … WebThe present study evaluated the comparative toxicological effects of diphenyl diselenide (PhSe) 2 and diphenyl ditelluride (PhTe) 2 in mice after in vivo administration. …
WebDec 11, 2013 · The acute liver failure (ALF) induced by acetaminophen (APAP) is closely related to oxidative damage and depletion of hepatic glutathione, consequently changes in cell energy metabolism and mitochondrial dysfunction have been observed after APAP overdose. Diphenyl diselenide [(PhSe)2], a simple organoselenium compound with … WebBisphenol A (BPA) is a chemical toxicant that has deleterious effects on human. BPA causes oxidative stress in tissues, including the liver. Diphenyl diselenide (PhSe) 2 improves the antioxidant response via activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/Kelch-like ECH-associated protein (keap 1) pathway in macrophage cells. In the …
WebAug 1, 2016 · Diphenyl Diselenide Reduces Oxidative Stress and Toxicity Caused by HSV-2 Infection in Mice: Diphenyl diselenide decreases HSV-2 toxicity August 2016 Journal of … WebSep 1, 2010 · The results suggest that (PhSe)2 may be useful for the treatment of cognitive impairment that may hold significant therapeutic value in alleviating certain memory deficits observed in Alzheimer's disease. This study was conducted to evaluate the effects of exposure to diphenyl diselenide (PhSe)2 on cognitive impairment induced by …
WebOct 24, 2024 · Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an …
WebAug 13, 2013 · A later study of the latter research group showed that daily treatment with diphenyl diselenide (5 lmol/kg) prevented MeHg-induced brain mitochondrial dysfunction, oxidative stress and reduction ... st. louis shriners hospitalWebDec 25, 2024 · Exposure to pesticide chlorpyrifos (CPF) is associated with neurodevelopmental toxicity both in humans and animals. Diphenyl diselenide (DPDS) is a … st. louis slim new orleansWebApr 18, 2024 · Methylmercury (MeHg) is a ubiquitous and persistent environmental pollutant that induces serious neurotoxic effects. Diphenyl diselenide [(PhSe)2], an organoseleno … st. louis slam women\u0027s football teamWebObjectives: This study investigated the involvement of different types of K(+) channels and PPARgamma receptors in the antidepressant-like effect of diphenyl diselenide in mice. Methods: Mice were pretreated with subeffective doses of K(+) channel inhibitors (tetraethylammonium, glibenclamide, charybdotoxin and apamin), openers (cromakalim, … st. louis slow pitch softball hall of fameWebMice were pretreated with Se-PTC (1–50 mg/kg), via the peroral route (p.o), 0.5 h before injection with acetate. Control animals received a similar volume of the vehicle (10 ml/kg, canola oil) as the negative, or Celecoxib(150 mg/kg,p.o.)asthepositivecontrol.Post-challenge,the mice were placed individually into separate boxes and the total st. louis team familiarly crosswordWebOct 1, 2024 · Moreover, topical treatment with the hydrogel containing (OMePhSe) 2 loaded-nanocapsules was more effective in reducing ear thickness and the inflammatory … st. louis sti/hiv prevention training centerWebDiphenyl diselenide (Ph 2 Se 2) is an organoselenium compound.Its crystalline structure,[] toxicokinetic properties,[] antioxidant and anti-inflammatory activities have been investigated.[] Its ability to reverse the oxidative brain damage and mitochondrial dysfunction induced by acetaminophen has been studied in mice.[] It reacts with thallium … st. louis sportswear inc